NMN - The Secret To Anti-Aging?

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NMN (Nicotinamide Mononucleotide): A Comprehensive Guide

Nicotinamide Mononucleotide (NMN) is a derivative of the B-vitamin niacin (vitamin B3). It has garnered significant attention in recent years for its potential anti-aging properties and numerous health benefits. This article will explore NMN's sources, health benefits, recommended dosage, potential risks, and the various supplements available on the market.

What is NMN?

NMN is a nucleotide that occurs naturally in all life forms. It is a crucial intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells that is essential for energy metabolism and cellular function. NAD+ levels decline with age, and maintaining these levels is believed to be important for healthy aging.

Sources of NMN

While NMN can be found in trace amounts in some foods, the levels are typically low. Here are some natural sources:

  1. Broccoli: Contains small amounts of NMN.
  2. Cabbage: Another vegetable with minor quantities of NMN.
  3. Avocado: Known for its healthy fats, it also provides some NMN.
  4. Edamame: Young soybeans are a good source.
  5. Tomatoes: Commonly consumed and contain NMN.

Health Benefits of NMN

  1. Anti-Aging: NMN supplementation has been shown to boost NAD+ levels, which can help mitigate the effects of aging. Higher NAD+ levels are associated with improved DNA repair, enhanced cellular energy production, and increased sirtuin activity (proteins that play a role in aging and longevity).
  2. Energy Metabolism: By boosting NAD+ levels, NMN helps improve mitochondrial function, which is crucial for converting nutrients into energy.
  3. Cognitive Function: NMN may support brain health by protecting neurons and enhancing cognitive functions, potentially reducing the risk of neurodegenerative diseases like Alzheimer's.
  4. Cardiovascular Health: NMN can improve blood vessel health and function, potentially reducing the risk of cardiovascular diseases.
  5. Metabolic Health: NMN may help improve insulin sensitivity and regulate blood sugar levels, benefiting those with or at risk of type 2 diabetes.
  6. Physical Performance: By enhancing muscle endurance and strength, NMN can improve physical performance and recovery.

Recommended Dosage

The optimal dosage of NMN for humans is still being researched. However, studies and clinical trials have provided some guidance:

  • General Health: 250-500 mg per day.
  • Anti-Aging and Longevity: Up to 1,000 mg per day.

It is essential to start with a lower dose and gradually increase it while monitoring your body's response. Consulting with a healthcare provider before starting NMN supplementation is recommended.

Potential Risks and Side Effects

NMN is generally considered safe and well-tolerated. However, some potential risks and side effects include:

  1. Gastrointestinal Issues: Some users may experience mild digestive discomfort, such as nausea, bloating, or diarrhea.
  2. Headaches: Occasionally, NMN can cause headaches.
  3. Unknown Long-Term Effects: As with many supplements, the long-term effects of NMN supplementation are not fully understood.

Remember, it is important to purchase NMN supplements from reputable brands to ensure purity and quality.

NMN Supplements

There are various NMN supplements available in the market, often available in capsule or powder form. Here are some popular options:

  1. Elysium Basis: A well-known supplement that combines NMN with pterostilbene, another compound thought to support health and longevity.
  2. Tru Niagen: Contains nicotinamide riboside (NR), a precursor to NMN, and is well-studied for its safety and efficacy.
  3. ProHealth NMN: Offers high-purity NMN in both capsule and powder form.
  4. Alive by Science Sublingual NMN: Provides a sublingual form of NMN for potentially better absorption.

 

NMN is a promising supplement with numerous potential health benefits, particularly in the realm of anti-aging and metabolic health. While research is ongoing, early findings suggest that NMN could be a valuable addition to a healthy lifestyle. As with any supplement, it is crucial to consult with a qualified healthcare professional before beginning use to ensure it is appropriate for your individual health needs.

*In a Singapore study of 18 NMN supplements on the market, researchers found some brands containing less NMN than what their labels claim. In fact, some NMN supplements contain no NMN at all. So it is important to do your research and buy only from reputable brands and reliable sources.

 

*findings presented at “Unlock Healthy Longevity Supplements Conference” organised by NUS Yong Loo Lin School of Medicine, 2024.


Article by Wellner Chan

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